Exploring Nature for Antidote for Corona Viruses

Exploring Nature for Antidote for Corona Viruses

Aeysha Sultan1, Iram Shahzadi2, Roberto Acevedo3*

1Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan

2Sargodha Medical College, University of Sargodha, Sargodha, Pakistan

3Facultad de Ingeniería, Arquitectura y Diseño, Universidad San Sebastián, Bellavista, Santiago, Chile

*Correspondence to: Roberto Acevedo

Citation: Sultan A, Shahzadi I, Acevedo R (2022) Exploring Nature for Antidote for Corona Viruses. Sci Academique 3(2): 1-09

Received: 08 October, 2022; Accepted: 25 October 2022; Publication: 29 October 2022


Coronavirus are known for their crown like morphology. Corona virus is a group of different form of virus that cause mild to severe respiratory diseases; the latest type of this group is known as Covid-19. Since its outbreak and then becoming world pandemic, intense research has been done for development of vaccine, interferon type therapies and drugs, to cure this pandemic which has claimed a lot lives. The natural pharmacopeia is treasure for searching plants and herbs for possible remedy. This commentary aims to highlight some plants as potential antidote for ailments caused by Corona viruses.

Keywords: Natural supplements; Corona Virus; Herbs; Antidote; Covid-19


Inspired by Corona virus’s appearance under microscope, the virus’s halo-like structure inspired scientists to name it as Corona. Corona viruses belong to the family Coronaviridae and are characterized by presence of club-shaped glycoprotein spikes in the envelope which give corona its coronal, appearance. The coronavirus genome consists of a single strand of positive-sense RNA. The nucleocapsid of these viruses is either helical or tubular. Depending upon the morphology of nucleocapsid, the corona viruses are divided into two genera, Coronavirus and Torovirus; former has helical capsid and later has tubular one.

Known for their ability to cause mild to moderate respiratory disorders in human, seven (07) various type of corona virus have been discovered; the first one been discovered in mid-1960s. each of these types can be further classified into one of the four sub-groups known as alpha, beta, gamma and delta. People around the world commonly get infected with human coronaviruses 229E, NL63, OC43, and HKU1. Sometimes coronaviruses that infect animals can evolve and become a new human coronavirus. Three recent examples of this are 2019-nCoV, SARS-CoV, and MERS-CoV. Figure 1 represents phylogenetic relationship between different forms of corona viruses.

Figure 1: Phylogenetic relationship between different forms of corona viruses.

Intensive research in going on to understand the mechanism how these viruses infect cells, cause disease and how these can be detected, prevented and cured. These seven types of cornonaviridae are tabulated as table 1:

Table 1: A comparison of various types of coronavirus.

Mechanism of action of Corona virus

The genome of corona virus consists of nearly 30000 nucleotides which code for four type of structure proteins:

Nucleocapsid (NC) protein: Nuclear capsid (NC-protein) of the corona viruses is enclosed in capsid (a protein shell). The N-terminal of the NC-protein which binds to genome (RNA) of virus is responsible for viral replication, replication and also for hijacking the human cell and turning them into virus manufacturing sites. Therefore, the mechanism of action of a drug effective against corona virus may involve blockage of N-terminus of NC-protein to prevent its binding with viral RNA.

 Membrane (M) protein: M-protein is found profusely on virus surface and is responsible for integrity of corona virus.

Spike (S) protein: S-Protein is assimilated over virus surface is responsible for attachment of virus to host cell receptors and also catalyzes the fusion of host and viral cell membranes and entry of virus into host cell (Kirchdoerfer, et al. 2016).

Envelop (E) protein and several non-structural proteins (nsp).: The E-protein plays an important role in virus assembly, membrane permeability of the host cell and virus-host cell interaction (Gupta, et al. 2020).

Hemagglutinin-esterase glycoprotein (HE): HE is a structural protein present only in beta corona viruses OC43 and HKU1. These proteins enhance uptake of viruses by the mucosal cells.

Various studies have revealed that the S-protein of the corona virus are made of glycoproteins of 3 identical chains, each with1273 amino acids. These spikes have S1 and S2 subunits which are associated with cell recognition and fusion of cell membrane of virus and host. The mechanism of fusion of cell membrane still remains to be characterized [1,2].

The virus enters into the host cell once coronavirus spike (S) protein attaches to angiotensin converting enzyme 2 (ACE2) receptors that is found on the surface of many human cells, including those in the lungs. host proteases enzymes cleave coronavirus S protein at two sites between subunit S1 and S2 which leads to activation of membrane fusion mechanism [3]. Finally, the viral genetic material is fully released into the cytoplasm where process of replication and transcription processes take place via formation of replication/transcription complex (RTC) made of non-structural proteins (nsp). As a result of these processes new nucleocapsids and structural viral proteins, M, S and E are synthesized in the cytoplasm and ultimately new virions are disseminated from infected cells so that these can infect other cells. 

A morphological comparison of corona and toro virus indicates that both types of virus have a lipid membrane, prominent 20 nm spike proteins (S) and an integral membrane protein (M). the purpose of spikes of corona and toro viruses is to mediate binding of virus to a specific glycoprotein receptor on the cell surface of host cell. HE is a nonessential protein that serve as initial or additional binding molecule the same protein assists in removal of the virus when attached to no susceptible cells or aiding in virus release. all beta coronaviruses, and some toroviruses, have an HE protein that forms a layer of 7 nm spikes. The envelope (E) protein is the smallest and least well-characterized of the four major structural proteins found in coronavirus virions. It is an integral membrane protein less than 110 amino acid residues long. Coronaviruses, but not toroviruses, contain a small number of molecules of an E protein. Sometimes, the plasma cells create abnormal proteins. These abnormal proteins are called M proteins, or monoclonal proteins. Cryoelectron microscopy has indicated the presence of a core structure in coronaviruses, comprising a nucleocapsid (NC: N protein plus genomic RNA) and the carboxyterminal endodomain of the M protein (M). The nucleocapsid of corona viruses is in form of a ring whereas that of toroviruses has the appearance of a torus [4].

Figure 1: Generalized representation of cornona and toroviruses.

Remedy of Corona Virus and Nature

From the ancient times, the role of natural plants and their derivatives for an effective disease management therapy has been recognized and with the passage of time, the significance of natural products and phytochemicals has increased and gained attention all around the world [5,6]. Earlier before the advent of antibiotics natural products were used [7-9]. Thus, the role of herbal medicine is not only recognized or significant for single disease management but for the management of plethora of all illness including for acute and chronic disease cases. Also, phytochemicals with their bioactive components are also effective against a number of viral pathogens such as influenza virus, dengue virus, measles virus, hepatitis B, C virus, HIV, enterovirus, corona virus and many more [10].

Medicinal herbs have been discovered and used in traditional medicine medical practices since prehistoric times. Plants synthesize hundreds of chemical compounds for functions including defense against insects, fungi, diseases, and herbivorous mammals. Numerous phytochemicals with potential or established biological activity have been identified. But the phytochemical content and pharmacological actions (if any) of many plants having medicinal potentials remain unassessed by scientific research to define efficacy and safety [11].

One major pattern that seems to be common to all corona viruses is that all causes symptoms related to cold and these symptoms are exacerbated in people with compromised immunity. Other symptoms include asthenia, myalgia, dyspnea, fever, cough (usually dry), pneumonia and thrombo-cytopenia,12,13 dysquesia, anosmia, fatigue and rapid heartbeat inclusive. Nature is quite rich in serving as source of potential remedy for a number of physiological disorders. Although the advancement in Science and Technology is touching new horizons, but still nature has its own importance and we seek nature for sudden outbreaks even in this era. Here, the role of nature in treating symptoms of Covid-19 will be discussed.

Number of beneficial herbs which effective for covid-19 include: Pericarpium citri reticulatae, Herba pogostemonis, Rhizome dioscoreae, Rhizome asari radix, Belamcandae, immaturus Aurantia fructus, Radix et rhizome asteris, Rhizome zingiberis recens, Radix bupleuri, Reticulatae citri, Fructus aurantii Pericarpium, decoction of gancao-ganjiang, decoction of Qingfeipaidu, fuzhengrecette qingfeitouxie, decoction of Sheganmahuang and Fibrosum polyporus gypsum are effective against coronavirus [14,15].

Natural products such as like Rein scutella, Myricetin and flavonoids have also been found to have good anti-viral properties [16] while methoxide-crypto pleurine, homo-harringtonine, silvestrol, ouabain, lycorine and tylophorine are reported to have potential to manage the COVID-19 viral infection [17].

Plant extracts are thought to be effective for the management with possible cure for corona virus infection [18-20]. These in combination with supplements such as vitamin c, zinc, elderberry (botanically known as Nigra sambucus), medicinal mushroom (also effective), licorice, Sidoides pelargonium, vitamin b complex, andrographis, garlic, selenium, astragalus, curcumin, propolis & echinacea are thought to be essential for boosting the immunity [21]. Moreover, Vitamin C and D are thought to be very effective against viral infection, reducing the chances of corona virus infection. From recent research, it was confirmed that, taking vitamin D orally reduces the chances of influenza and corona virus infection [22].

Other several important herbs, which have shown effectiveness against this virus includes: Baicalensis scutellaria (also known as skull-cap Chinese), Ginseng panax, Lucidum ganoderma, Zeylanica plumbago, Purpurea echinacea, bran white, alba lawsonia, aloe vera, velvet leaf, membranaceus astragalus and gigas angelica [23]. Also, along this line are; Lamba scythian, spider red lily, liquorice Chinese & and mahogany Chinese. Two important plant derived component baicalin and baicalein are found to be good inhibitors of corona virus [24-26].

Some common herbs (eg liquorice, cumin black, and garlic) which have shown significant pharmacological activities such as; anti-oxidant, anti-viral, anti-inflammatory, to enhance body immunity and to also improves gut problems. A number of traditional Chinese medicine may have played some significant role for the cure of corona virus. One of the important Chinese medicinal formula Lianhua qingwen has been found to suppress the moderate symptoms of Covid-19 patients [27]. Some other plants including: Purpura echinacea [28,29], astragalus [30] have shown good potency and effective control against this disease [31]. The table 1 show depicts supplements of plants origin with good response to corona virus infection, and hence and an antidote to infections due to COVID-19 exposure.

Table 2: Natural plants and supplements for corona virus.

Michaelis , Doerr, et al. (2011) demonstrated that phyto-chemicals show some inhibitory effects at early stage of COVID by inhibiting the replication, penetration and absorption [38]. Moreover, various medicinal herbs that could be targeted against covid-19 as there their bioactive components are thought to work via mechanistic processes that include inhibiting the replication process and can also stimulate the process of mediated cell immunity against several viruses [37]. The extract of Glabra glycyrrhiza (licorice) [39]and black seeds (Sativa nigella) [40], are known shown to be effective against severe acute respiratory syndrome for which coronavirus have been implicated [41,42] Other important plants with potential to act as anti-COVID-19 herbs are: Annua artemisia, Radiata lycoris, Lingua pyrrosia and Aggregate lindera [43].

Although the number of reports on use of herbs and plants / phytochemicals as potential remedy of Covid-19 is quite large, more efforts are needed in this area to explore the nature and help mankind in this pandemic.


Nature is very rich and we turn to it to find solution to our problems; and in one way or the other nature gives us a way through. In search of remedy for the Covid-19, exploring nature has indeed yielded some promising results which are worth exploring. More research is needed to check the active ingredient in various plants that have been found effective against this infectious disease which has claimed a large number of human lives.


  1. Walls AC, Park Y-J, Tortorici MA, Wall A, McGuire AT, Veesler D (2020) Structure, function, and antigenicity of the SARS-CoV-2 Spike glycoprotein. Cell 181: 281–212.
  2. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh C-L, Abiona O, Graham BS, McLellan JS (2020) Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367: 1260–1263.
  3. Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P (2005) Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proceedings of the National Academy of Sciences 102: 11876–11881.
  4. González JM, Gomez-Puertas P, Cavanagh D, Gorbalenya AE, Enjuanes L (2003) Taxonomical relations within the family Coronaviridae based on sequence identity analysis. Arch Virol 148: 2207–2235.
  5. Prasanna G, Ujwal A, Diliprajudominic S, Marimuthu T, Saraswathi N (2014) A new pipeline to discover antimycotics by inhibiting ergosterol and riboflavin synthesis: the inspirations of Siddha medicine. Medicinal Chemistry Research 23: 2651-2658.
  6. Oliveira AFCdS , Teixeira RR, d Oliveira AS, d Souza APM, M L d Silva and S O d Paula (2017) Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses. Molecules 22: 505.
  7. Cheng PW, LT Ng, LC Chiang, CC Lin (2006) “Antiviral effects of saikosaponins on human coronavirus 229E in vitro“. Clinical and Experimental Pharmacology and Physiology 33: 612-616.
  8. Lau K-M, K-M Lee, C-M Koon, CS-F Cheung, C-P Lau, H-M Ho, MY-H Lee, SW-N Au, CH-K Cheng and C Bik-San Lau (2008) “Immunomodulatory and anti-SARS activities of Houttuynia cordata ” Journal of Ethnopharmacology118: 79-85.
  9. Lin L-T , W-C Hsu, C -C Lin (2014) “Antiviral natural products and herbal medicines “, Journal of traditional and complementary medicine 4: 24-35.
  10. Maree J, A Viljoen (2012) “Phytochemical distinction between Pelargonium sidoides and Pelargonium reniforme—A quality control perspective”. South African Journal of Botany 82: 83-91.
  11. Ahn K (2017) The worldwide trend of using botanical drugs and strategies for developing global drugs”. BMB Reports 50: 111–116.
  12. Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF (2020) The proximal origin of SARS-CoV-2. Nature medicine 26: 450-452.
  13. Contini C, M Di Nuzzo, N Barp, A Bonazza, R De Giorgio, M Tognon, S Rubino (2020) “The novel zoonotic COVID-19 pandemic: An expected global health concern”. The Journal of Infection in Developing Countries 14: 254-264.
  14. Ganjhu RK , Mudgal PP, Maity H, Dowarha D, Devadiga S, Nag S, Arunkumar G (2015) “Herbal plants and plant preparations as remedial approach for viral diseases”. Virusdisease 26: 225-236.
  15. Arshad MS, Khan U, Sadiq A, Khalid W, Hussain M, Yasmeen A, Asghar Z, Rehana H (2020) “Coronavirus disease (COVID‐19) and immunity booster green foods: A mini review ” Food Science & Nutrition 8: 3971-3976.
  16. Ashour HM, WF Elkhatib, M Rahman, H A Elshabrawy (2020) “Insights into the recent 2019 novel coronavirus (SARS-CoV-2) in light of past human coronavirus outbreaks”. Pathogens 9: 186.
  17. Yu M-S , J Lee, JM Lee, Y Kim, Y-W Chin, JG Jee, Y-S Keum, Y-J Jeong (2012) “Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13”. Bioorganic & medicinal chemistry letters 22: 4049-4054.
  18. Velavan TP, CG Meyer (2020) “The COVID‐19 epidemic”. Tropical medicine & international health 25: 278.
  19. Victor A (2020) “Mathematical predictions for COVID-19 as a global pandemic”. Available at SSRN 3555879.
  20. Ramsden CE (2016) “Breathing easier with fish oil-a new approach to preventing asthma?”. The New England journal of medicine 375: 2596.
  21. Mahaffey BL, F CAQ, D Cort (2017) “MSMA Members in the News”. Missouri Medicine 114: 97.
  22. Ceylan Z, R Meral, T Cetinkaya (2020) “Relevance of SARS-CoV-2 in food safety and food hygiene: potential preventive measures, suggestions and nanotechnological approaches”. VirusDisease 31: 154-160.
  23. Tan BK, J Vanitha (2004) “Immunomodulatory and antimicrobial effects of some traditional Chinese medicinal herbs: a review ” Current medicinal chemistry 11: 1423-1430.
  24. Li S-y, C Chen, H-q Zhang, H-y Guo, H Wang, L Wang, X Zhang, S-n Hua, J Yu, P-g Xiao (2005) “Identification of natural compounds with antiviral activities against SARS-associated coronavirus”. Antiviral research 67: 18-23.
  25. Su H, S Yao, W Zhao, M Li, J Liu, W Shang, H Xie, C Ke, M Gao, K Yu (2020) “Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease invitro”. bioRxiv.
  26. Wen C-C , L-F Shyur, J-T Jan, P-H Liang, C-J Kuo, P Arulselvan, J-B Wu, S-C Kuo, N-S Yang (2011) “Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication”. Journal of traditional and complementary medicine 1: 41-50.
  27. Ding Y, L Zeng, R Li, Q Chen, B Zhou, Q Chen, P leng Cheng, W Yutao, J Zheng, Z Yang (2017) “The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function”. BMC complementary and alternative medicine 17: 130.
  28. Burger RA , AR Torres, RP Warren, VD Caldwell, BG Hughes (1997) “Echinacea-induced cytokine production by human macrophages”. International journal of immunopharmacology 19: 371-379.
  29. Elmowalid GA , MI Abd El-Hamid, AM Abd El-Wahab, M Atta, G Abd El-Naser, A M Attia (2019) “Garlic and ginger extracts modulated broiler chicks innate immune responses and enhanced multidrug resistant Escherichia coli O78 clearance”. Comparative immunology, microbiology and infectious diseases 66: 101334.
  30. Yoshida, Y, M Wang, J Liu, B Shan and U Yamashita (1997) “Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular”. International Journal of Immunopharmacology 19: 359-370.
  31. Young TK, JG Zampella (2020) “Supplements for COVID-19: A modifiable environmental risk”. Clinical Immunology (Orlando, Fla ).
  32. Islam MT, C Sarkar, D M El‐Kersh, S Jamaddar, S J Uddin, J A Shilpi, M S Mubarak (2020) “Natural products and their derivatives against coronavirus: A review of the non‐clinical and pre‐clinical data”. Phytotherapy Research 34: 2471-2492.
  33. Weng JR, Lin CS, Lai HC, Lin YP, Wang CY, Tsai YC, et al. (2019) Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63 Virus Res 273: 197767.
  34. Wen CC, Shyur LF, Jan JT, Liang PH, Kuo CJ, Arulselvan P, et al. (2011) Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication. J Trad Compl Med 1: 41-50.
  35. Sharifi N, Souri E, Ziai SA, Amin G, Amanlou M (2013) Discovery of new angiotensin converting enzyme (ACE) inhibitors from medicinal plants to treat hypertension using an in vitro assay. Daru 21: 74.
  36. Song YH, Kim DW, Curtis-Long MJ, Yuk HJ, Wang Y, Zhuang N, et al. (2014) Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits. Biol Pharm Bull 37: 1021–1028.
  37. Fiore C, M Eisenhut, R Krausse, E Ragazzi, D Pellati, D Armanini, J Bielenberg (2008) “Antiviral effects of Glycyrrhiza species”. Phytotherapy Research 22: 141-148.
  38. Michaelis M, HW Doerr, J Cinatl Jr (2011) “Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses”. Phytomedicine 18: 384-386.
  39. Chrzanowski J, A Chrzanowska, W Graboń (2020) “Glycyrrhizin: An old weapon against a novel coronavirus” Phytotherapy Research.
  40. Maideen NMP (2020) “Prophetic Medicine-Nigella Sativa (Black cumin seeds)–Potential herb for COVID-19?” Journal of pharmacopuncture 23: 62-70.
  41. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F (2013) A review on therapeutic potential of Nigella sativa: A miracle herb Asian Pacific journal of t Tropical b Biomedicine 3: 337-352.
  42. Cui, J D (2015) “Biotechnological production and applications of Cordyceps militaris, a valued traditional Chinese medicine”. Critical reviews in biotechnology 35: 475-484.
  43. Dajani E, T Shahwan, N Dajani (2016) “Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance”. J Physiol Pharmacol 67: 801-817.
  44. Tahir AH, Javed MM, Hussain Z (2020) “Nutraceuticals and herbal extracts: A ray of hope for COVID‑19 and related infections”. International Journal of Functional Nutrition 1: 1-1.
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