Epigenetic dysregulation and targeted interventions in acute myeloid leukemia: A review of IDH1, IDH2, and DNMT3A mutations
Abstract Mutations in DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 1 (IDH1), and IDH2 are prominent driver events in acute myeloid leukemia (AML), altering normal hematopoiesis through aberrant DNA and histone methylation. To
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